Advanced Certificate in Antibody Drug Conjugates and Combination Therapy
-- ViewingNowThe Advanced Certificate in Antibody Drug Conjugates and Combination Therapy is a comprehensive course designed to equip learners with critical skills in the rapidly evolving field of cancer therapeutics. This certificate program delves into the design, development, and optimization of Antibody Drug Conjugates (ADCs) and combination therapies, addressing their clinical applications and industrial demand.
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โข Introduction to Antibody Drug Conjugates (ADCs): Understanding the basic concepts, structure, and functionality of ADCs, including their components: monoclonal antibodies, linkers, and payloads.
โข Payload Selection and Design: Exploring various payload types, mechanisms of action, and factors affecting payload selection in ADCs.
โข Linker Technologies: Examining different linker chemistries, properties, and design considerations to optimize ADC stability and efficacy.
โข Antibody Selection and Engineering: Discussing monoclonal antibody selection criteria, engineering techniques, and optimization strategies for ADC development.
โข Analytical Methods for ADC Characterization: Investigating analytical tools, techniques, and best practices for characterizing ADCs, including mass spectrometry, HIC, SEC, and CE.
โข Preclinical Development and Toxicology: Covering preclinical study design, toxicology assessment, and regulatory requirements for ADCs.
โข Clinical Development and Translational Research: Examining clinical trial design, patient selection, biomarker identification, and pharmacokinetic/pharmacodynamic (PK/PD) modeling in ADC development.
โข Combination Therapy with ADCs: Evaluating the rationale, benefits, and challenges of combining ADCs with other therapeutic modalities, such as chemotherapy, immunotherapy, and targeted therapy.
โข Regulatory Affairs and Commercialization Strategies: Discussing global regulatory requirements, market access, and reimbursement strategies for ADCs.
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